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Symbol
Name
ID

Manf
mesencephalic astrocyte-derived neurotrophic factor
MGI:1922090

Phenotype annotations related to endocrine/exocrine glands

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Exocrine pancreatic insufficiency	Pancreatic adenocarcinoma
Disease(s) Associated with MANF
pancreatic cancer

Mouse Phenotypes		increased pancreas apoptosis	abnormal pancreatic beta cell differentiation	endocrine/exocrine gland phenotype	decreased pancreatic beta cell mass	decreased pancreatic beta cell number	decreased pancreatic islet number
Availability	Mouse Genotype	increased pancreas apoptosis	abnormal pancreatic beta cell differentiation	endocrine/exocrine gland phenotype	decreased pancreatic beta cell mass	decreased pancreatic beta cell number	decreased pancreatic islet number
	Manf^{tm1a(KOMP)Wtsi}/Manf^{tm1a(KOMP)Wtsi}
	Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} Tg(Nes-cre)1Kln/0 (conditional)			*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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